Naltrexone

Questions to Ask a Doctor About Naltrexone

A checklist to help you have a productive, informed conversation with a licensed clinician about naltrexone and the Sinclair Method.

Last updated: April 2025Editorial Policy

Educational Information Only

This site is for education only and is not a substitute for medical advice, diagnosis, or treatment. Always speak with a qualified, licensed clinician before making any decisions about medication or treatment. Naltrexone is a prescription medication and is not appropriate for everyone.

If you are considering speaking with a clinician about naltrexone and the Sinclair Method, having a prepared list of questions can help you make the most of your appointment. The following questions are organized by topic.

Questions About Your Candidacy

  • Am I a candidate for naltrexone given my medical history?
  • Do I need a liver function test before starting naltrexone?
  • Are there any medications I currently take that interact with naltrexone?
  • Do I have any conditions that would make naltrexone unsafe for me?
  • Have I been opioid-free long enough to safely start naltrexone?

Questions About the Sinclair Method

  • Are you familiar with the Sinclair Method (TSM)?
  • Would you be willing to prescribe naltrexone for use with the Sinclair Method protocol?
  • What dose would you recommend for the TSM protocol?
  • How should I take naltrexone — how long before drinking?
  • What should I do on days when I do not drink?

Questions About Monitoring and Follow-Up

  • How often should I check in with you while on naltrexone?
  • What lab tests do I need before starting and during treatment?
  • What signs of liver problems should I watch for?
  • How will we know if the treatment is working?
  • What should I do if I experience side effects?

Questions About Goals and Expectations

  • What outcomes should I realistically expect?
  • How long does the extinction process typically take?
  • Is the goal abstinence, or is controlled drinking also a valid outcome?
  • What happens if I need to stop naltrexone suddenly?
  • Are there other support resources you would recommend alongside naltrexone?

Talk to a Licensed Clinician

The information on this site is educational. Before starting naltrexone or any medication, speak with a licensed clinician who can evaluate your full medical history and individual circumstances.

Sources & References

  1. [1]Anton RF, et al. Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence. JAMA. (2006)
  2. [2]Volpicelli JR, et al. Naltrexone in the treatment of alcohol dependence. Archives of General Psychiatry. (1992)
  3. [3]FDA. Naltrexone Prescribing Information.
  4. [4]Garbutt JC. The state of pharmacotherapy for the treatment of alcohol dependence. Journal of Substance Abuse Treatment. (2009)