Plain-English summaries of the science behind naltrexone, pharmacological extinction, and the Sinclair Method.
Educational Information Only
This site is for education only and is not a substitute for medical advice, diagnosis, or treatment. Always speak with a qualified, licensed clinician before making any decisions about medication or treatment. Naltrexone is a prescription medication and is not appropriate for everyone.
How alcohol activates the brain's reward system and why this matters for understanding dependence.
The mechanism by which naltrexone blocks opioid receptors and reduces alcohol's rewarding effects.
A plain-English summary of the clinical evidence for TSM, including key trials and meta-analyses.
Overview of the evidence base for naltrexone as a treatment for alcohol use disorder.
The scientific mechanism behind how TSM gradually reduces alcohol reward and reinforcement.
What the GLP-1 comparison gets right and what it gets wrong about naltrexone and TSM.