The Sinclair Method Starter Guide

A plain-English guide to understanding naltrexone, alcohol cravings, pharmacological extinction, and the questions to ask before speaking with a licensed clinician.

Educational Information Only

This site is for education only and is not a substitute for medical advice, diagnosis, or treatment. Always speak with a qualified, licensed clinician before making any decisions about medication or treatment. Naltrexone is a prescription medication and is not appropriate for everyone.

What's in the Guide

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What the Sinclair Method is and how it works
The science of pharmacological extinction explained simply
What naltrexone is, how it works, and what it doesn't do
Who may be a candidate and who should be cautious
A checklist of questions to ask a licensed clinician
What to expect in the first weeks and months
Key research and sources

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Need Immediate Help?

If you are in immediate danger, call 911. For substance use support in the United States, contact SAMHSA's National Helpline: 1-800-662-HELP (4357) — free, confidential, 24/7.